成人原发性结肠嗜酸性粒细胞增多症和嗜酸性粒细胞结肠炎-华夏病理网月影灯
译者及来源
译者：柘城县人民医院 翟丽敏
来源：美国外科病理学杂志
摘要
成人结肠中嗜酸性粒细胞正常含量和嗜酸性结肠炎的病理组织学诊断标准仍未明确。本研究的目的：(1)确定正常成人结肠嗜酸性粒细胞的数量；(2)为结肠嗜酸性粒细胞增多和嗜酸性粒细胞结肠炎提出一个临床病理诊断框架安菲特里忒 。为实现这些目标，我们在159名成年人的正常左、右结肠及横结肠组织中统计嗜酸性粒细胞数量南大校草 。我们从120万例患者的活检数据库中找出所有诊断为成年人结肠嗜酸性粒细胞增多的患者，从地域、临床、病理资料方面回顾性分析了所有病例骊歌吉他谱，包括其他器官嗜酸性粒细胞增多的信息唐琳璐 。
然后，对有临床表现的患者(无明显病因的嗜酸性粒细胞增多的患者)与其他类型的结肠炎患者进行比较。金华外国语学校 右结肠、横结肠及左结肠的嗜酸性粒细胞正常计数(每毫米)分别为55.7±23.4、41.0±18.6、28.6±17.2。194例患者(嗜酸性粒细胞计数166 - 5050 /毫米)中63例无症状并且结肠镜检查是正常的。结肠镜检查最常见的适应症是腹泻和腹痛，在131例有症状、内镜异常或两者兼有中的患者中舍我妻谁，38%患者有腹泻、27%患者有腹痛症状。
临床和内镜表现均不足以怀疑到结肠嗜酸性粒细胞增多症。总之，原发性结肠嗜酸性粒细胞增多症是非常罕见的（发生率<1/ 6000）梅田彩佳 ，蒋申 1/3的患者是无症状的。患者的临床表现没有独特性，也不可能导致临床医生怀疑这种情况吞雷天尸，并且三分之一的患者无症状。我们建议规范报告结肠嗜酸性粒细胞增多可能会增加临床病理研究此病的机会玉衡子，而临床病理研究会对这一尚未明确的病变本质进行一个较好的定义。
Primary Colonic Eosinophilia and Eosinophilic Colitis in Adults.
Abstract
The normal content of eosinophils in the adult colon and the criteria for the histopathologic diagnosis of eosinophilic colitis remain undefined. This study aimed at: (1) establishing the numbers of eosinophils in the normal adult colon; and (2) proposing a clinicopathologic framework for the diagnosis of primary colonic eosinophilia and eosinophilic colitis. To accomplish these goals钱帅君 , we counted the eosinophils in the rightmc梦阳 , transverse艾衍含 , and left colon of 159 adults with normal colonic histology. Using a database of 1.2 million patients with colonic biopsies, we extracted all adults with a diagnosis of colonic eosinophilia.
We reviewed the slides from all cases and captured demographic陈金铭, clinical, and pathologic data, including information about eosinophilia in other organs. We then compared the clinical manifestations of the study patients (those with no identifiable cause of eosinophilia) to those of patients with other types of colitis. The normal eosinophil counts (per mm) were 55.7±23.4 in the right魔钢长剑, 41.0±18.6 in the transverse, and 28.6±17.2 in the left colon. Of the 194 study patients (eosinophil counts 166-5050/mm), 63 were asymptomatic and had a normal colonoscopy.
Diarrhea and abdominal pain were the commonest indications for colonoscopy (38% and 27%, respectively) among the 131 patients who had symptoms, endoscopic abnormalities, or both. Neither clinical manifestations nor endoscopic appearance were sufficiently characteristic to elicit the suspicion of colonic eosinophilia. In conclusion, primary colonic eosinophilia was extremely rare in this series (<1 in 6000 patients); one third of these patients were asymptomatic.
Their clinical manifestations were not distinctive and could not have led clinicians to suspect this condition; one third of the patients were asymptomatic. We suggest that regularly reporting high colonic eosinophilia may result in increased opportunities for clinicopathologic studies that might lead to a better definition of this still elusive entity.
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